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The CANBUILD project aims to engineer a complex three-dimensional human tumor microenvironment to study the interactions between malignant cells and immune cells. By recreating conditions similar to high-grade serous ovarian cancer metastases, the project seeks to improve cancer research and treatment testing.
Even at their earliest stages, human cancers are more than just cells with malignant potential.
Cells and extracellular matrix components that normally support and protect the body are coerced into a tumour microenvironment that is central to disease progression.
My hypothesis is that recent advances in tissue engineering, biomechanics and stem cell biology make it possible to engineer, for the first time, a complex 3D human tumour microenvironment in which individual cell lineages of malignant,…
QUEEN MARY UNIVERSITY OF LONDON
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