CORDIS Project
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This project investigates the role of Alu RNA sequences in cancer development, particularly their accumulation due to DICER1 deficiency. It aims to analyze Alu RNA expression and signaling in tumors, potentially identifying new therapeutic targets for cancer treatment.
Background and rationale:
The Alu repeat elements are the most abundant short interspersed repeated elements (SINEs) in human genome.
Recently, the accumulation of Alu RNA transcripts, following DICER1 deficit, has been shown to be responsible for a human disease, the dry form of age-related macular degeneration (AMD), Geographic Atrophy (GA).
Interestingly, increased levels of Alu RNAs and reduced DICER1 expression have been observed in several cancers, although no correlation has yet been esta…
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