CORDIS Project
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This project explores the mechanisms that prevent effective immunotherapy in cancers associated with human papillomavirus. By investigating the barriers to immune response, the research aims to develop strategies that enhance the efficacy of cancer treatments.
The frontier in cancer therapy of orchestrating the immune system to attack tumors is producing unprecedented survival benefit in some patients.
The corollary is lack of efficacy both in ostensibly responsive tumor types as well as others that are mostly non-responsive.
The basis lies in pre-existing and adaptive resistance mechanisms that circumvent induction of tumor-reactive cytotoxic T cells (CTLs) capable of infiltrating solid tumors and eliminating cancer cells. A priori, cancers induced b…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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