CORDIS Project
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This project investigates the interactions between calcium-dependent lectins and their ligands, focusing on their roles in bacterial and viral infections. By employing advanced molecular dynamics and quantum mechanical calculations, it aims to enhance understanding of lectin-ligand binding, which could lead to the deve…
Lectins are proteins that bind saccharides, thus mediating cell-cell and cell-pathogen adhesion.
They are therefore implicated in many devastating diseases (cancer, diabetes).
The pharmaceutical industry had to leverage the remarkable progress in modern methodologies to cope with the enormous challenges of targeting lectins (flexible interactions involving calcium, multivalent ligands/multimeric receptors), producing a dozen of successful glycomimetic drugs (e.g.
Tamiflu).
To develop workflows c…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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