CORDIS Project
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The CAJAL project investigates the role of Osteocalcin, a hormone from bones, in improving locomotor functions affected by aging. It focuses on understanding how this hormone influences motoneuron health and autophagy, aiming to develop new therapies for age-related mobility decline.
Brain aging is characterized by a progressive decline of our nervous system functions.
Elucidating the underlying mechanisms is of vital importance and represents an unmet medical need.
Recent studies have highlighted the molecular contribution of several organs in brain aging, and emphasize the importance of systemic milieu in the control of cognitive fitness.
Host has identified Osteocalcin (Ocn), a bone-derived hormone, as a rejuvenating systemic factor that improves memory in aged-mice.
Howe…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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