CORDIS Project
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This project aims to enhance cardiac muscle regeneration by studying the properties of adult cardiac progenitor cells and the role of telomerase. By understanding these mechanisms, the project seeks to develop potential therapies to improve heart muscle cell survival and engraftment.
Cardiac muscle death, unmatched by muscle cell creation, is the hallmark of acute myocardial infarction and chronic cardiomyopathies.
The notion of heart failure as a muscle-cell deficiency disease has driven interest worldwide in ways to increase heart muscle cell number, by over-riding cell cycle constraints, suppressing cell death, or, most directly, cell grafting.
Using stem cell antigen-1, we previously identified telomerase-expressing cells in adult mouse myocardium, which have salutary pr…
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