CORDIS Project
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This project investigates the underlying mechanisms of CADASIL, a rare vascular disease linked to cognitive decline, by exploring the effects of synthetic lipoxin mimetics on inflammation and fibrosis. It utilizes patient-derived models to identify dysfunctional pathways and immune cell interactions, aiming to develop…
CADASIL, a rare disease of the small blood vessels, is caused by mutations in NOTCH3 and can cause cognitive decline leading to dementia.
Vascular disease is the second most common cause of dementia with the burden set to increase with population aging.
Insights into CADASIL will prove instrumental in understanding and treating the vascular contributions to cognitive impairment and dementia (VCID).
There are no therapies for CADASIL and a lack of translational human models for identification of…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI NON PROFIT CORPORATION
United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United States, Boston
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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