CORDIS Project
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This project aims to understand the role of a chloride channel, Anoctamin-6, in microglial cells related to neuropathic pain. By profiling microglial expression and characterizing Ano6, the research seeks to uncover mechanisms of neuron-microglia communication that could lead to new pain treatments.
Neuropathic pain is a significant worldwide health problem that is poorly understood and often untreatable. A major factor in the pathogenesis of neuropathic pain is an activation of microglial cells in the spinal cord.
Following damage to peripheral nerves, these activated cells release factors that increase excitability in spinal pain circuitry.
Using expression profiling studies of microglial cells the host laboratory discovered a putative chloride channel transcript that is highly upregulate…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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