CORDIS Project
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This project aims to develop a recombinant antivenom called Latrotoxumab, a fully human monoclonal antibody that neutralizes the toxic effects of widow spider bites. It seeks to provide a safer, more effective, and cost-competitive alternative to existing horse-derived antivenoms, addressing supply chain issues and adv…
Widow spiders are spread worldwide, and their bite induces severe envenomation symptoms that can lead to a complex syndrome known as latrodectism and death in severe cases.
The only available specific treatment consists of polyclonal antibodies derived from horse plasma obtained by hyperimmunization with black widow spider venom.
However, this process is slow, dangerous, and implies the continuous use of large domestic animals (mainly horses) in the manufacturing process.
Venom unavailability is…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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