CORDIS Project
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This project focuses on understanding how hematopoietic stem cells are generated from endothelial cells during embryonic development. It aims to develop a culture protocol for blood vessel organoids to study the formation of these cells and their response to mechanical forces, which could enhance future treatments for…
Hematopoietic stem cells (HSCs), responsible for generating all blood cells, are produced during embryonic development in the aorta of the aorta-gonad-mesonephros (AGM) region.
This process involves specialized endothelial cells (ECs), called hemogenic endothelial cells (HECs), undergoing an endothelial-to-hematopoietic transition (EHT), which leads to the formation of HSC precursors (pre-HSCs) that mature into functional HSCs.
However, the regulation of HEC specification and EHT remains poorly…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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