CORDIS Project
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This project explores the stochastic nature of gene transcription in single cells, focusing on transcriptional bursting. By using advanced imaging techniques, it aims to understand how gene expression variability affects cell behavior and fitness.
Transcription in single cells is a stochastic process that arises from the random collision of molecules, resulting in heterogeneity in gene expression in cell populations.
This heterogeneity in gene expression influences cell fate decisions and disease progression.
Interestingly, gene expression variability is not the same for every gene: noise can vary by several orders of magnitude across transcriptomes.
The reason for this transcript-specific behavior is that genes are not transcribed in a c…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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