CORDIS Project
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This project investigates the mechanisms behind the burst-pause response of cholinergic interneurons in the striatum, particularly in the context of Parkinson's disease. By using advanced techniques like optogenetics and calcium imaging, it aims to identify potential therapeutic targets to improve motor function in aff…
Our ability to attend to novel stimuli requires an intact projection from the parafascicular (PF) nucleus of the thalamus to the cholinergic interneurons (ChIs) of the striatum.
ChIs respond to novel stimuli with a burst-pause (B-P) in their tonic firing.
The B-P response is a neural correlate of classical conditioning, and as such shows a large degree of plasticity in response to behavioral contingencies.
The B-P response (and its plasticity) are severely compromised in animal models of Parkins…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
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