CORDIS Project
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This project develops a Brain Organoid-on-Chip platform to study neocortical development and neurodevelopmental disorders like autism and intellectual disabilities. By creating a more complex 3D model using microfluidic technology, it aims to enhance understanding and testing of pharmaceutical interventions.
A human model of neocortical development to understand neurodevelopmental disorders such as autism spectrum disorders or intellectual disability is urgently needed.
Neural 2D cultures derived for example from induced pluripotent stem cells (iPSC) have been used for many years but lack the complexity of the tissue environment essential for the functionality of the developing neocortex. A promising approach to provide controlled microenvironments that generate physiological conditions and allow co…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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