CORDIS Project
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The BREPOCI project investigates the effects of recombinant human erythropoietin on cognitive function and brain cell development in neuropsychiatric conditions. It explores how this growth factor influences brain plasticity and could lead to new therapies for intellectual disabilities and autism linked to specific gen…
Cognitive disability and decline play key roles in neuropsychiatric conditions but lack effective therapies.
Erythropoietin (EPO) is a hypoxia-inducible growth factor, named after its original description in erythropoiesis.
We discovered - by 'reverse approach' (human trials first) - that recombinant human (rh) EPO has potent procognitive effects, hematopoiesis-independent.
Searching for mechanistic insight in mice, we saw that rhEPO markedly drives differentiation/maturation of pyramidal neuron…
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