CORDIS Project
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This project explores the role of Wnt signaling in breast cancer by examining how it activates DNA damage response pathways. It aims to identify molecular mechanisms that could be targeted for therapeutic interventions in cancers influenced by Wnt signaling.
Wnt signaling is important in many developmental processes and has been implicated in tumorigenesis and in degenerative diseases.
In normal cells, Wnt family proteins act through the well characterized canonical or less well understood non-canonical signaling pathways.
While the canonical pathways proceed through the stabilization of beta-catenin, the non-canonical ones involve several effectors including protein kinases such as JNK, a member of the Stress Activated Protein Kinases family, which…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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