CORDIS Project
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This project investigates the interaction between CD44, RANK, and AKT in cancer stem cells, focusing on their roles in breast cancer metastasis and resistance to treatment. By understanding this crosstalk, the project aims to identify specific markers that could help predict patient responses to therapies targeting the…
Relapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant to chemotherapy.
The RANK signalling pathway is implicated in a number of cancers and notably in breast carcinogenesis and metastasis.
Inhibition of this pathway reduces CSCs decreasing both recurrenceRelapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant…
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