CORDIS Project
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BREAK-OUT aims to improve the management of thoracic aortic aneurysm by unraveling the mechanisms behind the disease and developing new therapies. The project will utilize patient-derived models to enhance pre-clinical research and potentially reverse aneurysm formation.
Thoracic aortic aneurysm (TAA) entails a high risk for aortic dissection and rupture, which is a prominent cause of death in Western countries.
Prophylactic surgery significantly reduces the mortality risk, but complications are relatively common.
Moreover, in severe TAA conditions aneurysms often develop at other locations afterwards, exposing patients to repeated surgeries and, thus, threats.
Current drug options only modestly slow down dilatation, without preventing dissections or ruptures. C…
UNIVERSITEIT ANTWERPEN
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