CORDIS Project
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This project investigates how cancer cells interact with their surrounding environment in tumors driven by BRCA1/2 mutations. By analyzing the microenvironments of breast, ovary, pancreas, and prostate cancers, it aims to identify common design principles that could inform more effective, targeted therapies.
Tumors are ecosystems in which cancer cells interact with diverse cell populations.
In each such ecosystem, environmental conditions, cellular compositions and paracrine signaling create a distinct tumor habitat.
How much the composition of the habitat is dictated by the organ versus specific mutations in the cancer cells is unknown.
If different organs and mutations have common microenvironmental design principles, one could devise more general therapy.
Otherwise, therapy must be mutation and o…
WEIZMANN INSTITUTE OF SCIENCE
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