CORDIS Project
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The project aims to develop a small molecule that can inhibit the interaction between RAD51 and BRCA2 proteins, which is crucial for DNA repair in cancer cells. This could enhance the effectiveness of existing cancer treatments by targeting a specific mechanism of resistance.
The proposed research is to develop a small molecule as drug candidate compound for the treatment of cancer.
We will use fragment-based methods to disrupt the protein-protein interaction between the human recombinase RAD51, and the hub protein BRCA2.
This interaction is essential for DNA repair by homologous DNA recombination (HDR), a key cellular pathway involved in the resistance of cancer cells to ionizing radiation and radio-mimetic drugs.
The target site (i.e.
Velcro pocket) is unique to RA…
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