CORDIS Project
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This project explores the role of the BRCA2 gene in the response of prostate cancer cells to radioligand therapy. By studying how BRCA2 deficiency affects treatment outcomes and immune response, the research aims to identify potential biomarkers for patient selection and improve therapeutic strategies.
Despite current advances in prostate cancer (PCa) treatment, 10 to 20% of PCa will evolve to a metastatic stage, where the overall survival is 14 months.
Radioligand therapy (RLT) is a new, promising treatment consisting in the injection of a radiolabelled vector.
In PCa, this therapy targets Prostate Specific Membrane Antigen, which is overexpressed on PCa cells compared to other tissues. RLT has been shown to increase the overall survival of patients in clinical trials, but in order to improve…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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