CORDIS Project
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This project focuses on understanding focal cortical dysplasia type II, a condition causing drug-resistant epilepsy in children. By developing a mosaic cortical organoid model, it aims to investigate the developmental origins and mechanisms of this condition, potentially leading to new treatment strategies.
Epilepsy, a global neurological disorder affecting around 70 million people, poses a significant medical challenge, with one-third of patients facing drug-resistant epilepsy.
Cortical malformations such as focal cortical dysplasia type II (FCDII) are associated with pediatric drug-resistant epilepsy for which surgical intervention serves as the main therapeutic approach for seizure control. FCDII is marked by cortical dyslamination and the presence of abnormal cytomegalic cells.
Recent findings…
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
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