CORDIS Project
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This project explores the brain circuits involved in regulating body weight and energy homeostasis through non-hormonal communication with white adipose tissue. It aims to identify new therapeutic targets for obesity by understanding these mechanisms.
Disruption of energy homeostasis can lead to obesity, a major health issue worldwide.
Therapeutic efforts to reduce adiposity are nullified by metabolic adaptations.
The mechanisms underlying these phenomena are unclear, precluding efficient intervention.
Although it is well established that important hormonal factors control adiposity, it is less appreciated that fat (white adipose tissue, WAT) is innervated by sympathetic and sensory fibres forming, with discrete brain nuclei, loop circuits. T…
KAROLINSKA INSTITUTET
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