CORDIS Project
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This research focuses on pericytes, cells that regulate blood flow in the brain, particularly during strokes. It aims to uncover the mechanisms behind their function and develop strategies to prevent their constriction and death, which contribute to various neurological diseases.
Pericytes, located at intervals along capillaries, have recently been revealed as major controllers of brain blood flow.
Normally, they dilate capillaries in response to neuronal activity, increasing local blood flow and energy supply.
But in pathology they have a more sinister role.
After artery block causes a stroke, the brain suffers from the so-called “no-reflow” phenomenon - a failure to fully reperfuse capillaries, even after the upstream occluded artery has been reperfused successfully.…
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