CORDIS Project
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This project explores the role of mRNA stability in neural differentiation during brain development. It aims to investigate how regulated mRNA decay influences cell fate decisions in neuroblasts and ganglion mother cells.
During brain development, neural stem cells (neuroblasts) divide asymmetrically to produce a neuroblast and a neural progenitor cell, the ganglion mother cell (GMC), which will later divide to produce two neurons or glia.
Asymmetric protein localization and transcriptional activation are two well-established mechanisms that influence cell fate decisions during this process. I hypothesize that a relatively unexplored regulatory component—mRNA stability—also plays a major role in neural differenti…
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