CORDIS Project
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This project investigates how cancer cells navigate physiological barriers during metastasis. By studying molecular signals at the tumor-stroma and endothelial borders, it aims to uncover mechanisms that facilitate cancer spread and identify potential therapeutic targets.
During dissemination, cancer cells must face and overcome several physiological borders, including the immediate stroma for local invasion and the endothelium for long-distance metastasis.
At these critical junctures, cell plasticity between epithelial (E) and mesenchymal (M) states could determine metastasis potential.
Based on our preliminary data, ideally-positioned cues emanating from the normal stroma contain the tumour in situ.
Once this first border is breached, rare cancer cell-endotheli…
TURUN YLIOPISTO
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