CORDIS Project
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This project investigates how enveloped viruses, particularly bunyaviruses, enter host cells by studying the fusion of viral and cell membranes. Using advanced imaging techniques, it aims to uncover the molecular mechanisms of virus entry, which could inform the development of vaccines and antiviral drugs.
We aim to understand host cell entry of enveloped viruses at molecular level. A crucial step in this process is when the viral membrane fuses with the cell membrane.
Similarly to cell–cell fusion, this step is mediated by fusion proteins (classes I–III).
Several medically important viruses, notably dengue and many bunyaviruses, harbour a class II fusion protein.
Class II fusion protein structures have been solved in pre- and post-fusion conformation and in some cases different factors promoting…
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United Kingdom, Oxford
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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