CORDIS Project
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This project develops user-friendly bioinformatics tools for analyzing mass spectrometry data on protein structures. It aims to automate the identification and quantification of proteins using advanced cross-linking techniques, facilitating research in structural biology.
Mass spectrometry-based chemical cross-linking (XL-MS) is an emerging field to study protein structures, conformations and interactions.
Despite its great potential, the data analysis part hinders its widespread applications for a variety of reasons.
First, an arduous manual validation is still used in many laboratories.
Second, most of the available bioinformatics tools are limited to conventional cross-linkers and not the new type of cross-linkers:
MS-cleavable cross-linkers which are key to s…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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