CORDIS Project
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This project focuses on developing a new cross-coupling method using Suzuki−Miyaura coupling to enable the use of challenging 1,1-bisboryl alkanes in asymmetric reactions. It aims to enhance synthetic organic chemistry, particularly in drug development and materials science, by improving the incorporation of complex be…
Suzuki−Miyaura coupling (SMC) has emerged as a powerful strategy in the field of cross-coupling reactions and is widely used in synthetic organic chemistry and drug development.
Asymmetric SMC reactions employing aryl/alkenyl boronic acid is well developed; however, no general Csp3 – Csp3 Suzuki-Miyaura coupling is currently available.
Furthermore, the asymmetric addition of benzylic nucleophile or 1,1-difunctionalized reagents as a nucleophile is quite rare.
This proposal aims to develop a gene…
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