CORDIS Project
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This project investigates how transcription complexes are formed and regulated in eukaryotic cells. It focuses on understanding the assembly, nuclear import, and action of these complexes, which play a crucial role in gene expression.
Transcriptional regulation of protein coding genes in eukaryotic cells requires a complex interplay of sequence-specific DNA-binding factors, co-activators, general transcription factors (GTFs), RNA polymerase II and the epigenetic status of target sequences.
Nuclear transcription complexes function as large multiprotein assemblies and are often composed of functional modules.
The regulated decision-making that exists in cells governing the assembly and the allocation of factors to different tra…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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