CORDIS Project
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BioTisSeal focuses on creating advanced tissue sealants that enhance wound healing by combining bioactive properties with tunable elasticity. The project aims to develop off-the-shelf hydrogel sealants that not only close wounds but also promote tissue regeneration through controlled release of growth factors.
Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden.
Current tissue sealant formulations that are used for wound care pose various limitations, including inability for filling in larger defects and release of toxic by-products (especially from synthetic polymers).
Additionally, most of the commercial sealants provide no bioactive properties, or at best rely on bulk GF loading for inducing cell infiltration or t…
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