CORDIS Project
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This project investigates how the bacterium Bacillus subtilis manages cellular differentiation to cope with environmental changes. It aims to control this differentiation to improve enzyme production, enhancing the efficiency of industrial fermentation processes.
To cope with an ever changing environment, bacteria often develop a bet-hedging strategy like bi-stable cellular differentiation, resulting in cell populations with different properties.
For example, the industrially relevant model bacterium Bacillus subtilis can become motile, genetically competent, secrete degradative enzymes, or sporulate, and these cellular differentiations can occur simultaneously in a single genetically homogenous population.
This cellular heterogeneity exhibited by bacter…
UNIVERSITEIT VAN AMSTERDAM
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