CORDIS Project
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This project focuses on developing a computational framework for designing enzymes that can catalyze new reactions. By combining insights from enzymatic catalysis with advanced computational tools, it aims to enhance biocatalysis for various applications.
Enzymes are nature’s most efficient catalysts, enabling complex reactions with remarkable speed and selectivity.
However, their scope is limited by evolutionary pressures, restricting their utility in synthetic and industrial applications.
While enzyme engineering has achieved significant advancements, major challenges remain.
Directed evolution has been transformative, but it is labor-intensive and relies on suitable starting scaffolds.
Computational enzyme design is promising complementary str…
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