CORDIS Project
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The project aims to uncover the biophysical mechanisms behind the adhesion strength of gap junctions, which are crucial for cell communication. By using advanced biochemistry and biophysical techniques, it seeks to measure the forces between connexon pairs in cell membranes.
Gap junctions are intercellular channels present in almost all epithelia and in many other specialized tissues.
The correct function and formation of gap junctions are involved in diseases such as hypertension, deafness or cataracts.
Gap junctions are formed by pairs of hexameric half-channels called connexons, which coaxially dock to connect two adjacent cells, assuring communication, signalling and adhesion between cells.
Junctional microdomains are known to be form by thousands of closely pac…
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