CORDIS Project
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This project aims to develop advanced biophysical tools to study G-quadruplex structures in nucleic acids, which are important for gene regulation. It focuses on characterizing interactions between small molecules and these structures to enhance anticancer strategies.
There is now increasing evidence that specific nucleic acid structures modulate gene expression levels both at the transcriptional and at the translational level.
In particular, G-quadruplex (G4) structures are attractive targets for anticancer strategies, since several studies showed that their stabilization by ligands caused proliferation arrest, telomere deprotection and changes in gene expression.
Understanding the structure-function relationships in G4 DNA and RNA requires innovative biophy…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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