CORDIS Project
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This project aims to develop glycan-based nanoprobes for the targeted delivery of antibiotics to bacteria, addressing antimicrobial resistance. It combines materials chemistry and microbiology to create effective labeling and drug release systems.
Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR).
Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion.
These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand.
This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a…
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