CORDIS Project
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This project focuses on using DNA nanotechnology to create precise protein patterns that can influence immune responses. By designing DNA nanotemplates for antibodies and aptamers, it aims to study and control the activation of the Complement pathway, potentially leading to targeted therapies for cancer treatment.
Protein nanopatterning concerns the geometric arrangement of individual proteins with nanometre accuracy.
It is becoming apparent that protein nanopatterns are essential for cellular function, and have roles in cell signalling and protection, phagocytosis and stem cell differentiation.
Recent research indicates that our immune system is activated by nanopatterned antibody platforms, which initiate the classical Complement pathway by binding to the first component of Complement, the C1 complex. D…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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