CORDIS Project
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This project explores how manipulating the nuclear structure of human mesenchymal stem cells can enhance their differentiation potential. It utilizes innovative nanotechnology to deliver non-coding RNAs that may regulate epigenetic status for regenerative therapies.
Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies.
In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA.
The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus.
Interestingly, nuclear mechanics and shap…
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