CORDIS Project
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This project investigates how genes in Escherichia coli can enhance the production of integral membrane proteins, specifically G protein-coupled receptors, which are crucial drug targets. By optimizing bacterial hosts, the research aims to improve the yield and functionality of these proteins for pharmaceutical applica…
Eukaryotic cells express integral membrane proteins (IMP) that exchange substances with their environment or receive signals in the form of small molecules, peptides or proteins.
Most human IMPs are inherently difficult to study, because of complications in obtaining adequate amounts of stable and functional proteins. G protein-coupled receptors (GPCRs) are the largest IMP family in the human genome and constitute the most important class of drug targets in pharmaceutical discovery.Escherichia c…
University of Zurich
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