CORDIS Project
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This project investigates mobile genetic elements called conjugative transposons that transfer antibiotic resistance among bacteria. It aims to understand their impact on host fitness and the mechanisms that allow them to persist in bacterial populations without selective pressure.
Conjugative transposons (cTns) are mobile genetic elements that mediate the transfer of antibiotic resistance to a wide range of bacteria including enterococci.
Preliminary data revealed that the cTns, Tn6000, confer negligible burden or biological cost on enterococcal hosts.
Our hypothesis is therefore: cTns have evolved regulatory mechanisms that can minimize their transcription.
This leads to minimal biological cost to the host cell and stability of the mobile element within the population, e…
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