CORDIS Project
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This project focuses on designing and synthesizing new organic compounds that target adenine-binding proteins, particularly kinases involved in cancer. The compounds will mimic the interactions of ATP with these proteins and will be evaluated through biological assays.
Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases.
The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology.
The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing olefin metathesis and…
Masarykova univerzita
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