CORDIS Project
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This project explores a novel approach to managing heart rhythm disturbances by engineering cardiac tissue to autonomously detect and terminate arrhythmias. Utilizing gene transfer and specific proteins, the goal is to create a biological system that can respond to and correct these life-threatening conditions without…
Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device.
Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer.
In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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