CORDIS Project
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This project investigates how transcription factors locate specific binding sites in large genomes, focusing on the role of long intrinsically disordered regions in binding specificity. By studying yeast transcription factors, it aims to develop a new model explaining the efficiency of these searches and the molecular…
How transcription factors (TFs) bind rapidly at specific sites within large genomes remains a major mystery.
Specificity is puzzling since TFs select a small fraction of their potential binding sites - short and highly abundant DNA motifs.
Rapid detection of these selected sites is challenging due to the small motif size and the large number of non-specific sites within a genome.
Despite extensive efforts, a unifying model accounting for these challenges, underlying the foundations of gene regul…
WEIZMANN INSTITUTE OF SCIENCE
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