CORDIS Project
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This project explores how bilirubin, a product of heme breakdown, may protect tissues from damage during infections. It aims to understand its role in modulating immune responses and promoting tissue health.
The immune system was shaped through evolution, primarily through the selective pressure imposed by pathogens.
This led to the emergence of multiple mechanisms that limit the negative impact of pathogens on host health and fitness.
The best recognized defense strategy against infections relies on resistance mechanisms that aim at pathogen containment, expulsion or clearance.
While crucial for host survival to infection, resistance mechanisms can carry significant trade-offs, often driven by oxid…
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