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BiFOLDOME investigates the concept of co-assembly in proteins, particularly focusing on amyloids formed by multiple distinct proteins. The project aims to enhance our understanding of protein assembly processes, which could lead to advancements in manipulating disease-related proteins and developing new methodologies f…
Self-assembly is a fundamental foundation of life, but what about co-assembly?
The main goal of BiFOLDOME is to decipher co-assembly to understand self-assembly.
Amyloids were assumed to be assembled by one type of protein, but our recent elucidation of the first 1:1 hetero-amyloid structure (the RIPK1-RIPK3 necrosome core) suggests that amyloids composed of two distinct proteins playing key roles in health and disease may be common.
In fact, a viral protein (M45) can displace one partner…
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