CORDIS Project
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This project investigates the role of specific harmful bacteria in colorectal cancer development. It aims to engineer a probiotic strain that can detect and eliminate these bacteria by disrupting their biofilms, potentially leading to new diagnostic and therapeutic strategies for colorectal cancer and related intestina…
Colorectal cancer (CRC) development and progression have been linked to the presence of pro-oncogenic bacterial strains in the intestine, such as Fusobacterium nucleatum, pks+ Escherichia coli and enterotoxigenic Bacteroides fragilis.
These pathogenic bacteria produce toxins that can disrupt gut epithelial integrity resulting in heightened pro-inflammatory response, enhanced DNA mutations, and increased cell proliferation, which can eventually lead to adenoma formation.
In addition, these bacter…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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