CORDIS Project
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This project focuses on understanding the membrane proteins Apt1 and Cdc50 from the fungal pathogen Cryptococcus neoformans, which are potential targets for antifungal drug development. The research aims to identify inhibitors and study the function of these proteins to combat infections in immunocompromised patients.
Cryptococcus neoformans is an opportunist fungal pathogen lethal for patient with AIDS.
Treatment options are limited and there is an urgent need for the discovery of anti-fungal drugs.
The membrane proteins Apt1 and Cdc50 from C. neoformans were identified as potential drug targets since it is involved in antifungal resistance and pathogen’s virulence.
Apt1 belongs to the P4-type ATPase family and together with Cdc50 proteins they are involved in the maintenance of phospholipid asymmetry in bio…
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