CORDIS Project
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This project investigates the unique mitochondrion-like organelles in the Blastocystis parasite, exploring their metabolic functions and adaptations to anaerobic conditions. By characterizing these organelles, the research aims to enhance understanding of mitochondrial evolution and function across diverse eukaryotes.
Blastocystis is a unicellular human intestinal parasite, of controversial pathogenicity, that belongs to a diverse eukaryotic phylum called the Stramenopiles.
Since Blastocystis is a strict anaerobe, it was thought that it might possess hydrogenosomes, anaerobic ATP-generating organelles related to mitochondria.
In contrast to typical hydrogenosomes, Blastocystis has mitochondrion-like organelles (MLOs) with cristae, a transmembrane potential and DNA.
Recent work has demonstrated a mitochondrial…
UNIVERZITA KARLOVA
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