CORDIS Project
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This project investigates the physiological and molecular mechanisms that regulate the replication of pancreatic beta cells, which are crucial for maintaining insulin production. By utilizing advanced genetic tools, the research aims to uncover the signaling pathways involved in beta cell division and their relationshi…
A fundamental challenge of pancreas biology is to understand and manipulate the determinants of beta cell mass.
The homeostatic maintenance of adult beta cell mass relies largely on replication of differentiated beta cells, but the triggers and signaling pathways involved remain poorly understood.
Here I propose to investigate the physiological and molecular mechanisms that control beta cell replication.
First, novel transgenic mouse tools will be used to isolate live replicating beta cells and…
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