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The BetaSpReg project investigates how specific proteins regulate the development and function of insulin-producing cells in diabetes. By utilizing advanced genetic techniques and human cell models, it aims to understand splicing mechanisms and explore new therapeutic approaches for metabolic diseases.
Diabetes mellitus affects over 500 million people worldwide and arises from the progressive loss of functional insulin-producing beta cells.
While transcriptional and epigenetic regulation of beta cells has been studied extensively, the role of alternative splicing, a fundamental mechanism that expands transcriptome and proteome diversity, remains poorly understood in this context.
The BetaSpReg project aims to uncover how splicing regulators of the hnRNP family control beta cell development, fu…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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