CORDIS Project
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This project explores how alternative splicing affects pancreatic beta cells in Type 1 diabetes, focusing on the role of inflammation in cell death. It aims to identify splicing networks that could be targeted for new therapies to prevent beta cell loss.
Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells.
The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell fate between survival or death remain to be clarified.
Alternative splicing (AS) is a complex mechanism of gene expression regulation and a potent generator of proteome diversity.
It provides cel…
UNIVERSITE LIBRE DE BRUXELLES
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